This screening test is performed between 11 and 13 weeks and six days of pregnancy and uses ultrasound and a blood test. This screening test is used to determine your risk of a chromosomal abnormality (Down Syndrome or Trisomy 21, Trisomy 18 and Trisomy 13) and the development of early-onset preeclampsia in this pregnancy.
1. Determination of risk of chromosomal abnormality:
The ultrasound will examine the fluid-filled space at the back of your baby’s neck (nuchal translucency) and for the development of your baby’s nasal bone. Your chance of Down Syndrome is higher if the nuchal translucency measurement is higher and/or if the nasal bone is not visible.
A blood test accompanies the scan. It measures two proteins in the mother’s blood (Free Beta hcG and PaPP-A). These two pregnancy-related proteins are produced by the placenta. The blood test is collected between nine weeks and 13 weeks and six days but preferably before the ultrasound is performed. The combination of the blood test, nuchal translucency measurement, nasal bone and the mother’s age gives an overall risk for Trisomy 21, Trisomy 18 and Trisomy 13.
If the adjusted risk is less than 1:300, your risk is considered low risk. However, this does not mean no risk. If the adjusted risk is greater than 1:300, the risk is considered high risk. In the event of a high-risk result, Dr Norris will discuss your options which includes non-invasive prenatal tasting (NIPT) and invasive prenatal testing (chorionic villous sampling or amniocentesis).
2. Determination of risk of early-onset preeclampsia:
Determination of risk of early-onset preeclampsia: Preeclampsia is the development of high blood pressure which is unique to pregnancy. This can lead to problems for the mother and baby during the pregnancy including premature delivery of the baby which can be most pronounced before 34 weeks gestation. To determine your risk of early-onset preeclampsia, in addition to the measurement of PaPP-A and another placental protein PlGF, we will assess the blood flow to the uterus (uterine artery pulsitility index), check your blood pressure and take a medical history. This information can be combined to determine your risk.
If you are found to be high risk (greater than 1:50), you will be advised to take a low dose of aspirin. There would also be close monitoring of your blood pressure during your pregnancy.
3. Other benefits of the first trimester scan:
- Confirm pregnancy viability
- Check your due date
- Diagnose twin pregnancy
- Early review of the fetal body parts
- Check the maternal pelvis including uterus and cervical length, ovaries and fallopian tubes